Tomás Pérez-Acle

Proyectos y Fondos

1. 2008 - 2010

   Sistema de Aprendizaje Colaborativo Basado en Infraestructura Grid (SACGRID): Aplicaciones en Ciencias Biológicas y Biotecnología

   FONDEF TIC-EDU. Project number TE08I1021 Director
2. 2008 – 2014

   Proyecto Financiamiento Basal (PFB16)

   Fundación Ciencia para la Vida Co-investigador
3. 2010 – 2015

   Instituto Milenio Centro Interdisciplinario de Neurociencias de Valparaíso (CINV)

   P09-022-F Associated Researcher
4. 2010 – 2015

   Laboratorio Nacional de Computación de Alto Rendimiento (National Laboratory for High Performance Computing, NLHPC) (ECM-02)

   Primer Concurso de Centros de Servicios de Equipamiento Mayor de uso Compartido. Programa de Investigación Asociativa, CONICYT. Centro de Modelamiento Matemático (CMM), Facultad de Ciencias Físicas y Matemáticas, Universidad de Chile Deputy Director
5. 2012

   Climatización Datacenter Facultad de Ciencias Físicas y Matemáticas para Supercomputador Centro de Modelamiento Matemático (AIC-49)

   FONDEQUIP, Programa de Investigación Asociativa PIA, CONICYT. Universidad de Chile Director
6. 2011 – 2014

   Red Iberoamericana de Supercomputación (RISC) (Iberoamerican Supercomputing Network)

   Grant Agreement 288883 for European Economic Community FP-07 Associated Researcher
7. 2012 – 2015

   Integración de la Biología Estructural al Desarrollo de la Bionanotecnología

   Anillo Científico y Tecnológico (ACT11007). Cuarto Concurso Nacional de Proyectos de Anillos de Investigación en Ciencia y Tecnología 2011 Principal Investigator

Mentorías

Research Lines

Publications

1. Molecular basis of ligand dissociation in B-adrenergic receptors

   González A, Perez-Acle T, Pardo L, Deupi X.

   2011

2. Nanoinformatics: an emerging area of information technology at the intersection of bioinformatics, computational chemistry and nanobiotechnology

   González-Nilo F, Pérez-Acle T, Guínez-Molinos S, Geraldo DA, Sandoval C, Yévenes A, Santos LS, Laurie VF, Mendoza H, Cachau RE.

   2011

3. Calpain inhibitors prevent p38 MAPK activation and germ cell apoptosis after heat stress in pubertal rat testes

   Lizama C, Lagos CF, Lagos-Cabré R, Cantuarias L, Rivera F, Huenchuñir P, Pérez-Acle T, Carrión F, Moreno RD.

   2009

4. Computational modeling study of functional microdomains in cannabinoid receptor type 1

   Gonzalez A, Duran LS, Araya-Secchi R, Garate JA, Pessoa-Mahana CD, Lagos CF, Perez-Acle T.

   Bioorg Med Chem. 2008 Apr 15;16(8):4378-89. Epub 2008 Feb 26 2008

5. Hantavirus Gc glycoprotein: evidence for a class II fusion protein

   Tischler ND, Gonzalez A, Perez-Acle T, Rosemblatt M, Valenzuela PD.

   J Gen Virol. 2005 Nov;86(Pt 11):2937-47 2005

Projects and Funding

1. 2005-2007

   Search for new non-nucleoside HIV-1 reverse transcriptase inhibitors: Design, synthesis and biological evaluations of new benzoimidazolic derivatives

   FONDECYT-Chile. Project number 1050950 Co-investigator
2. 2002-2005

   Genomic and gene expression studies in Vitis: viral infection response and detection kits development

   FONDEF-Chile. Project number GS02001 Co-investigator
3. 2006-2007

   Development of lead compounds as fusion inhibitors for Dengue virus (phase I)

   ITC-Americas – Research Development and Engineering Command (RDECOM), US-ARMY, USA. Project number 06-001(2006) Director
4. 2007

   Development of coarse-grained force fields to study thermal diffusion in supercomputer clusters

   Hewlett Packard Laboratories USA (Palo Alto, CA). Project number HPLABS-2007CHI001 Director
5. 2008-2009

   Development of lead compounds as fusion inhibitors for Dengue virus (phase II)

   US Army Medical Research and Materiel Command, project number W81XWH-08-1-0285 Director
6. 2008 - 2009

   International Cooperative Action on Grid Computing and Biomedical Informatics between the European Union, Latin America, the Western Balkans and North Africa

   ACTION-Grid project. Support Action 224176 for European Economic Community FP-07 Co-investigator
7. 2008

   Multidisciplinary studies of biological membranes onto SiO2 surfaces for applications in Bionanotechnology

   Programa Interdisciplinario VRAID 2008. Pontificia Universidad Católica de Chile Director
8. 2008 - 2009

   Natural-derivative compounds as novel varroicidal

   Fundación COPEC-UC Sexto Concurso de Proyectos de Desarrollo de Recursos Naturales Co-investigator
9. 2010 – 2013

   Multidisciplinary studies of organic chain molecules and biological membranes onto solid surfaces for applications in Nanotechnology

   Proyecto FONDECYT Regular 2010. Project number 1100882 Co-investigator
10. 2009 – 2012

    Pro-inflammatory conditions increase the permeability of the cell membrane through pathways that offer new therapeutic targets for human diseases

    Anillo Científico ACT71-Biomed 2009. Tercer Concurso Nacional de Proyectos de Anillos de Investigación en Ciencia y Tecnología 2009 Colaborator
11. 2011 – 2016

    CIRIC Foundation. INRIA Chile.

    CORFO Programme to Attract International Centres of Excellence for Competitivity. Research Line Omics and Bioinformatics Co-investigator (Subproject Identification of Molecular Interactions)
12. 2013 – 2016

    Transdisciplinary studies based on computational biology, molecular biology, and electrophysiology, to get insights into the structure-function relationships coded into the molecular architecture of Cx26 hemichannels and Gap Junction channels

    Proyecto FONDECYT Regular 2013 1130652 Director
13. 2014 – 2017

    Experimental and theoretical characterization of supported lipid bilayers as biosensor prototypes for applications in nanotechnology

    Proyecto FONDECYT Regular 2014 1141105 Co-investigator

Teaching

Mentoring